v5.1.0.3
Glycine data from LIS
Type | Family |
Description | This entry represents the mitochondrial/chloroplastic transcription termination factors (MTERFs). In humans four MTERFs have been identified (MTERF1-4). MTERF1 was first identified as a factor responsible for terminating heavy strand transcription at a specific site at the leu-tRNA, thereby modulating the ratio of mitochondrial ribosomal RNA to mRNA [ ]. Later, MTERF1 was found to stimulate transcriptional initiation [] and appeared to be in the control of mitochondrial replication pausing []. From a structural study, it binds to dsDNA containing the termination sequence and unwinds the DNA molecule, promoting base eversion, which is critical for transcription termination []. |
Short Name | MTERF |