Protein Domain : Transcription termination factor, mitochondrial/chloroplastic IPR003690

Type  Family
Description  This entry represents the mitochondrial/chloroplastic transcription termination factors (MTERFs). In humans four MTERFs have been identified (MTERF1-4). MTERF1 was first identified as a factor responsible for terminating heavy strand transcription at a specific site at the leu-tRNA, thereby modulating the ratio of mitochondrial ribosomal RNA to mRNA [ ]. Later, MTERF1 was found to stimulate transcriptional initiation [] and appeared to be in the control of mitochondrial replication pausing []. From a structural study, it binds to dsDNA containing the termination sequence and unwinds the DNA molecule, promoting base eversion, which is critical for transcription termination [].
Short Name  MTERF

0 Child Features

24 Gene Families

1000 Genes

2 Ontology Annotations

0 Parent Features

14 Publications

USDA
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