Protein Domain : BTB/POZ domain IPR000210

Type  Domain
Description  The BTB domain (Broad-Complex, Tramtrack and Bric a brac) is also known as the POZ domain (POxvirus and Zinc finger). It is a homodimerization domain occurring at the N terminus of proteins containing multiple copies of eitherzinc fingers of the C2H2 type or Kelch repeats [ , ]. Many BTB proteins are transcriptional regulators that are thought to act through the control of chromatin structure.The structure of the BTB domain of the promyelocytic leukemia zinc finger (PLZF) protein has been determined by X-ray crystallography and reveals atightly intertwined dimer with an extensive hydrophobic interface [ ]. A surface-exposed groove lined with conserved amino acids is formed at the dimer interface, suggesting a peptide-binding site.
Short Name  BTB/POZ_dom

30 Child Features

1 Gene Families

5076 Genes

1 Ontology Annotations

0 Parent Features

14 Publications

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