v5.1.0.3
Glycine data from LIS
Type | Domain |
Description | Eukaryotes have developed an evolutionarily conserved process, termed autophagy, to survive starvation conditions. The vacuole or lysosome mediates the turnover and recycling of non-essential intracellular material for re-use in critical biosynthetic reactions. ATG2 (also known as Apg2) is required for the formation and/or completion of cytosolic sequestering vesicles that are needed for vacuolar import through both the Cvt pathway and autophagy, as well as for the specific degradation of peroxisomes. ATG2 is a peripheral membrane protein that localises to the previously identified perivacuolar compartment that contains Apg9 [ ].This entry represents the C-terminal domain of ATG2 and related proteins such as VPS13, which contains two to three predicted amphipathic helices (AHs) that anchors these proteins to mitochondria, late endosomes or lipid droplets [ , , , ]. This domain is required for membrane recruitment and localisation []. |
Short Name | Atg2/VPS13_C |