Protein Domain : Atg2/VPS13, C-terminal IPR015412

Type  Domain
Description  Eukaryotes have developed an evolutionarily conserved process, termed autophagy, to survive starvation conditions. The vacuole or lysosome mediates the turnover and recycling of non-essential intracellular material for re-use in critical biosynthetic reactions. ATG2 (also known as Apg2) is required for the formation and/or completion of cytosolic sequestering vesicles that are needed for vacuolar import through both the Cvt pathway and autophagy, as well as for the specific degradation of peroxisomes. ATG2 is a peripheral membrane protein that localises to the previously identified perivacuolar compartment that contains Apg9 [ ].This entry represents the C-terminal domain of ATG2 and related proteins such as VPS13, which contains two to three predicted amphipathic helices (AHs) that anchors these proteins to mitochondria, late endosomes or lipid droplets [ , , , ]. This domain is required for membrane recruitment and localisation [].
Short Name  Atg2/VPS13_C

0 Child Features

1 Gene Families

80 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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