LIS - Legume Information System
Information about legume traits for crop improvement
GlycineMine
v5.1.0.3
Glycine data from LIS
v5.1.0.3
Glycine data from LIS
| Type | Family |
| Description | Glycation is a nonenzymatic covalent reaction between proteins and endogenous reducing sugars or dicarbonyls (methylglyoxal, glyoxal) that results in protein inactivation. DJ-1 was described in vitro as a protein deglycase that repaired methylglyoxal- and glyoxal-glycated proteins [ , ]. Since then there have been reports against [], and supporting this role for DJ-1 [].Furthermore, supporting its deglycase activity, DJ-1 and its bacterial homologues have been shown to be able to repair methylglyoxal- and glyoxal-glycated nucleotides and nucleic acids [ ]. This ability would make DJ-1 a target for diabetic and cancer research []. DJ-1, also known as Park7, has been associated with human parkinsonism [].Included in this family is also YajL from Escherichia coli, the bacterial homologue of DJ-1 [ , ]. This group of proteins are classified as either DJ-1 putative peptidases or non-peptidase homologues in MEROPS peptidase family C56 (clan PC(C)). |
| Short Name | DJ-1 |
