LIS - Legume Information System
Information about legume traits for crop improvement
GlycineMine
v5.1.0.3
Glycine data from LIS
v5.1.0.3
Glycine data from LIS
| Type | Family |
| Description | This entry represents a family of tRNA (uracil-5-)-methyltransferase homologues ( ), mainly found in metazoa, including tRNA (uracil-5-)-methyltransferase homologue A (TRMT2A) and B (TRMT2B) from human. TRMT2A catalyses the formation of 5-methyl-uridine in tRNAs and some mRNAs [ , , ]. TRMT2A/B mainly catalyse the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs [, ]. This family also includes the plant homologue AtC3H24 (also known as TRNA METHYLTRANSFERASE 2B) [] and putative RNA methyltransferases R405/407 from Acanthamoeba polyphaga mimivirus.Methyltransferases (EC [intenz:2.1.1.-]) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [, , ]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM []. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [, , ]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [, , ]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor. |
| Short Name | TRM2_met |
