v5.1.0.3
Glycine data from LIS
Type | Domain |
Description | Ephrins and their receptors EphR play an important role in cell communication in normal physiology, as well as in disease pathogenesis [ , ]. Binding of the ephrin (Eph) ligand to EphR requires cell-cell contact, since both molecules are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling, depending on Eph kinase activity) and ephrin-expressing cells (reverse signaling) [, , ]. Eph signaling controls cell morphology, adhesion, migration and invasion. Ephrins can be subdivided into two groups, A and B, depending on their respective receptors EphA or EphB. The nine human EphA receptors bind to five GPI-linked ephrin-A ligands and the five EphB receptors bind to three transmembrane ephrin-B ligands []. Interactions are promiscuous within each class, and some Eph receptors can also bind to ephrins of the other class.Ephrin Bs have several conserved tyrosine phosphorylation sites in their cytoplasmic PDZ-like domain, which are important for signal transduction [ ]. All ephrin Bs contain a highly conserved receptor binding ectodomain described in this entry. |
Short Name | Ephrin-B_Ecto |