v5.1.0.3
Glycine data from LIS
Type | Domain |
Description | This entry represents the ligand-binding domain found in ephrin type-B receptor 2 (EphB2). EphB2 plays a role in cell positioning in the gastrointestinal tract by being expressed in proliferating progenitor cells [ ]. It also has been implicated in colorectal cancer [, ]. A loss of EphB2, as well as EphA4, also precedes memory decline in a murine model of Alzheimers disease [].Class EphB receptors bind to transmembrane ephrin-B ligands. There are six vertebrate EhpB receptors (EphB1-6), which display promiscuous interactions with three ephrin-B ligands [ ].Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) [ ]. |
Short Name | EphB2_rcpt_lig-bd |