LIS - Legume Information System
Information about legume traits for crop improvement
GlycineMine
v5.1.0.3
Glycine data from LIS
v5.1.0.3
Glycine data from LIS
| Type | Domain |
| Description | Sad1/UNC-84 (SUN)-domain proteins are inner nuclear membrane (INM) proteins that are part of bridging complexes linking cytoskeletal elements with the nucleoskeleton. Originally identified based on an ~150-amino acid region of homology between the C terminus of the Schizosaccharomyces pombe Sad1 protein and the Caenorhabditis elegans UNC-84 protein, SUN proteins are present in the proteomes of most eucaryotes. In addition to the SUN domain, these proteins contain a transmembrane sequence and at least one coiled-coil domain and localise to the inner nuclear envelope. SUN proteins are anchored in the inner nuclear envelope by their transmembrane segment and oriented in the membrane such that the C-terminal SUN domain is located in the space between the inner and outer nuclear membrane. Here, the SUN domain can interact with the C- terminal tail of an outer nuclear envelope protein that binds to the cytoskeleton, including the centrosome [ , , ].Some proteins known to contain a SUN domain are listed below:Fission yeast spindle pole body-associated protein Sad1.Yeast spindle pole body assembly component MPS3, essential for nuclear division and fusion.Yeast uncharacterised protein SLP1.Caenorhabditis nuclear migration and anchoring protein UNC-84.Caenorhabditis SUN domain-containing protein 1 (sun-1), involved in centrosome attachment to the nucleus.Mammalian sperm-associated antigen 4 protein (SPAG4), may assist the organisation and assembly of outer dense fibres (ODFs), a specific structure of the sperm tail.Mammalian sperm-associated antigen 4-like protein (SPAG4L).Mammalian SUN1.Mammalian SUN2.Mammalian SUN3.Klaroid protein from Drosophila melanogaster [ ]. |
| Short Name | SUN_dom |
