Protein Domain : PI31 proteasome regulator, N-terminal IPR021625

Type  Domain
Description  PI31 is a regulatory subunit of the immunoproteasome which is an inhibitor of the 20S proteasome in vitro. PI31 is also an Fbxo7.Skp1 binding partner. Fbxo7 is an F-box protein, which are the substrate-recognition components of the Skp1-Cul1-F box protein (SCF) E3 ubiquitin ligases. The interaction between PI31 and Fbxo7.Skp1 occurs via the beta sheets of a N-terminal domain present in both proteins and known as FP(Fbxo7/PI31) domain. The structure of PI31 FP domain contains a novel alpha/β-fold and two intermolecular contact surfaces [ ].This entry represents the N-terminal domain of the PI31 proteasome regulator.
Short Name  PI31_Prot_N
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0 Child Features

1 Gene Families

Trail: ProteinDomain

112 Genes

Trail: ProteinDomain

0 Ontology Annotations

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13 Publications

Trail: ProteinDomain
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