Protein Domain : Saposin B type, region 2 IPR008138

Type  Domain
Description  Saposins are small lysosomal proteins that serve as activators of various lysosomal lipid-degrading enzymes []. They probably act by isolating thelipid substrate from the membrane surroundings, thus making it more accessible to the soluble degradative enzymes. All mammalian saposinsare synthesized as a single precursor molecule (prosaposin) which contains four Saposin-B domains, yielding the active saposins after proteolyticcleavage, and two Saposin-A domains that are removed in the activation reaction. The Saposin-B domains also occur in other proteins, many of them active in the lysis of membranes [, ].
Short Name  SapB_2

0 Child Features

0 Gene Families

953 Genes

0 Ontology Annotations

0 Parent Features

13 Publications

USDA
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