Protein Domain : Helicase/SANT-associated domain IPR014012

Type  Domain
Description  The helicase/SANT-associated (HSA) domain is found in eukaryotic proteins, including Helicase SRCAP/p400/DOM [ ], Probable global transcription activator SNF2L2/brahma-homologue and Chromatin modification-related protein EAF1 []. While each family has the core sequences that define the HSA domain, they each also have additional sequences that distinguish these families from one another. For example, the sequence HWDY(L/C)EEEM(Q/V) is found in the SRCAP/p400/DOM family, whereas the sequence HQE(Y/F)LNSILQ is found in the SNF2 /brahma family [].HSA was initially predicted to be a DNA-binding domain [ ], but it was later reported to be responsible for the binding to nuclear actin-related proteins (ARPs) and actin []. In addition to the SANT and helicase domains, the HSA domain is also found in association with the bromo domain [].
Short Name  HSA_dom

0 Child Features

2 Gene Families

418 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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