Protein Domain : Alpha-N-acetylglucosaminidase, C-terminal IPR024732

Type  Domain
Description  Alpha-N-acetylglucosaminidase is a lysosomal enzyme required for the stepwise degradation of heparan sulphate [ ]. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB, or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations []. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold [].
Short Name  NAGLU_C
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0 Child Features

2 Gene Families

Trail: ProteinDomain

134 Genes

Trail: ProteinDomain

0 Ontology Annotations

0 Parent Features

14 Publications

Trail: ProteinDomain
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