Protein Domain : Uridine kinase IPR026008

Type  Family
Description  This entry represents a family of uridine kinase proteins [ ].Uridine kinase (pyrimidine ribonucleoside kinase) is the rate-limiting enzyme in the pyrimidine salvage pathway. It catalyses the following reaction:ATP + Uridine = ADP + UMP A cDNA for uridine kinase from mouse brain was found which encodes a protein of 277 amino acids. A truncated form of the cDNA was expressed in Escherichia coli, and shown to display uridine kinase activity and to readily form a tetramer, the most active form of the wild-type enzyme. Sequence analysis has identified three ATP-binding site consensus motifs. The predicted secondary structure, and sequence comparison with kinases of known structure, is consistent with uridine kinase having the alpha/beta core nucleotide-binding fold common to many kinases [].
Short Name  Uridine_kinase_

0 Child Features

4 Gene Families

976 Genes

3 Ontology Annotations

1 Parent Features

14 Publications

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