Protein Domain : Forkhead-associated (FHA) domain IPR000253

Type  Domain
Description  The forkhead-associated (FHA) domain [ ] is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity for phosphothreonine-containing epitopes but will also recognise phosphotyrosine with relatively high affinity. It spans approximately 80-100 amino acid residues folded into an 11-stranded β-sandwich, which sometimes contain small helical insertions between the loops connecting the strands []. To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not archaeal genomes. The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes - DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples.
Short Name  FHA_dom

1 Child Features

0 Gene Families

1000 Genes

1 Ontology Annotations

0 Parent Features

13 Publications

USDA
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