v5.1.0.3
Glycine data from LIS
Type | Family |
Description | This entry includes lantibiotic ABC transporter permease subunit MutG which is a highly hydrophobic, integral membrane protein, and part of the bacitracin ABC transport system that confers resistance to the Gram-positive bacteria in which this system operates, specifically to lantibiotic mutacin. This protein transports mutacin to the surface and expels it from the membrane. Lantibiotics are small peptides, produced by Gram-positive bacteria, which are ribosomally-synthesized as pre-peptides and act by disrupting membrane integrity. Genes encoding the lantibiotic ABC transporter subunits are highly organized in operons containing all the genes required for maturation, transport, immunity, and synthesis [ , , ]. This protein family is largely restricted to gallidermin-family lantibiotic cassettes, but also include orphan transporter cassettes in species that lack candidate lantibiotic precursor and synthetase genes [, ]. Members of this group of proteins are predominantly found in Firmicutes and some species of Actinobacteria. |
Short Name | ABC-transptr_permeasesu |