Protein Domain : Orotidine 5'-phosphate decarboxylase, active site IPR018089

Type  Active_site
Description  Orotidine 5'-phosphate decarboxylase (OMPdecase) [ , ] catalyses the last step in the de novobiosynthesis of pyrimidines, the decarboxylation of OMP into UMP. In higher eukaryotes OMPdecase is part, with orotate phosphoribosyltransferase, of a bifunctional enzyme, while the prokaryotic and fungal OMPdecases are monofunctional protein. Some parts of the sequence of OMPdecase are well conserved across species. The best conserved region is located in the N-terminal half of OMPdecases and is centred around a lysine residue which is essential for the catalytic function of the enzyme.
Short Name  OMPdecase_AS
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0 Child Features

0 Gene Families

202 Genes

Trail: ProteinDomain

2 Ontology Annotations

Trail: ProteinDomain

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13 Publications

Trail: ProteinDomain
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