Protein Domain : Methylthioribose kinase IPR009212

Type  Family
Description  Members of this family are 5-methylthioribose kinases ( ) that catalyse phosphorylation of 5-methylthioribose (MTR), a step in the recycling of methionine from 5'-methylthioadenosine, a co-product of polyamine biosynthesis. The preceding step of methylthioadenosine (MTA) hydrolysis to MTR is catalysed by 5'-methylthioadenosine/S-adenosylhomocysteine (MTA/AdoHcy) nucleosidase. Bacillus subtilis protein MtnK (formerly YkrT) [ ] and Klebsiella pneumoniae protein MtrK [] have been experimentally characterised. K. pneumoniae MtrK expression is regulated by methionine [].As this enzyme is absent in mammals, it has been considered a target for rational drug design.
Short Name  Methylthioribose_kinase
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0 Child Features

1 Gene Families

Trail: ProteinDomain

127 Genes

Trail: ProteinDomain

2 Ontology Annotations

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14 Publications

Trail: ProteinDomain
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