Protein Domain : NGX6/PGAP6/MYMK IPR021910

Type  Family
Description  Proteins in this family include PGAP6 (also known as TMEM8A), NGX6 (also known as TMEM8B) and myomaker (also known as TMEM8C). TMEM8C is embedded in the plasma membrane with seven membrane-spanning regions and a required intracellular C-terminal tail. It is essential for myoblast fusion and sufficient to promote fusion of fibroblasts with muscle cells [ ]. TMEM8A and TMEM8B has no fusogenic activity. TMEM8A is a GPI-specific phospholipase A2 involved in Nodal signaling modulation through CRIPTO shedding []. TMEM8B plays a role in cell adhesion modulation in nasopharyngeal carcinoma cells [].
Short Name  NGX6/PGAP6/MYMK

0 Child Features

1 Gene Families

227 Genes

1 Ontology Annotations

0 Parent Features

14 Publications

USDA
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