Ontology Term : Pfam:PF03637 Mob1/phocein family EMBL-EBI

Description  Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature [1]. This family also includes phocein Swiss:Q9QYW3, a rat protein that by yeast two hybrid interacts with striatin [2].
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