Protein Domain : Proteasome activator complex subunit 4 C-terminal domain IPR021843

Type  Domain
Description  This domain is typically between 142 to 163 amino acids in length is found at the C terminus of activator complex subunit 4 (gene name PSME4, PA2000 or BLM10), a component of the 19S cap complex of the eukaryotic 26S proteasome. The tertiary structure of BLM10 from Saccharomyces cerevisiaehas been solved, showing that the C terminus is important for helping to form the BLM10 cap that covers the entry pore of the proteasome, restricting access for potential substrates. The C-terminal residues bind in the pocket between proteasome subunits alpha5 and alpha6, in a similar site to where the C-termini of the ATPases of the 19S proteasomal cap also bind [ ].
Short Name  PSME4_C

0 Child Features

1 Gene Families

73 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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