v5.1.0.3
Glycine data from LIS
Type | Family |
Description | This entry represents vacuolar protein sorting-associated protein 35 (Vps35) from eukaryotes. Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway [ , ]. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed of Vps26, Vps29 and Vps35 and is responsible for binding to and sorting protein cargo []. Mutations in the Vps35 gene have been linked to Parkinson's disease [ ]. Structurally, VPS35 forms a horseshoe-shaped, right-handed, α-helical solenoid []. |
Short Name | Vps35 |