v5.1.0.3
Glycine data from LIS
Type | Family |
Description | This entry represents a group of transcriptional adaptors, including transcriptional adapter 2 (TADA2) from animals and plants, and Ada2 from yeasts.Ada2 is a component of the SAGA/ADA coactivator complex, which regulates numerous cellular processes by coordinating histone acetylation [ , ]. There are two Drosophila Ada2 homologues, dAda2a and dAda2b. dAda2b is a component of Spt-Ada-Gcn5-acetyltransferase (SAGA) complexes, while dAda2a associates with dGcn5 but is not incorporated into dSAGA-type complexes [ ]. Mammalian TADA2 is a component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. The ATAC complex is involved in mammalian development, histone acetylation, cell cycle progression, and prevention of apoptosis during embryogenesis [ ]. |
Short Name | Ada2/TADA2 |