Protein Domain : DSS1/SEM1 IPR007834

Type  Family
Description  This family includes yeast Sem1 and its mammalian homologue, DSS1.Sem1/DSS1 (also known as rpn15) is a component of lid subcomplex of 26S proteasome regulatory subunit [ , , ]. Besides being a subunit of the 26S proteasome, Sem1/DSS1 associates with other protein complexes []. It is a component of the nuclear pore complex (NPC)-associated TREX-2 complex that is required for transcription-coupled mRNA export, and the COP9 signalosome, which is involved in deneddylation [, , ]. Loss of DSS1 in humans has been associated with split hand/split foot malformations [ ].
Short Name  DSS1_SEM1
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0 Child Features

1 Gene Families

Trail: ProteinDomain

206 Genes

Trail: ProteinDomain

3 Ontology Annotations

Trail: ProteinDomain

0 Parent Features

14 Publications

Trail: ProteinDomain
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