v5.1.0.3
Glycine data from LIS
Type | Conserved_site |
Description | Eukaryotic translation initiation factor 4E (eIF-4E) [ ] is a protein thatbinds to the cap structure of eukaryotic cellular mRNAs. eIF-4E recognises and binds the 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiationof protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwinding of its secondary structures. eIF-4E is a conserved protein of about 25kDa. Site directed mutagenesis experiments have shown [ ] that a tryptophan in the central part of the sequence of human eIF-4E seems to be implicated in cap-binding. The signature pattern used in this entry includes this tryptophan. |
Short Name | TIF_eIF_4E_CS |