Protein Domain : Peptide chain release factor 2 IPR004374

Type  Family
Description  Peptide chain release factors (RFs) are required for the termination of protein biosynthesis [ ]. At present two classes of RFs can be distinguished. Class I RFs bind to ribosomes that have encountered a stop codon at their decoding site and induce release of the nascent polypeptide. Class II RFs are GTP-binding proteins that interact with class I RFs and enhance class I RF activity. In prokaryotes there are two class I RFs that act in a codon specific manner []: RF-1 (gene prfA) mediates UAA and UAG-dependent termination while RF-2 (gene prfB), which is represented by this entry, mediates UAA and UGA-dependent termination. RF-1 and RF-2 are structurally and evolutionary related proteins which have been shown [] to be part of a larger family.This entry represents peptide chain release factor 2 (PrfB, RF-2). It also includes chloroplastic release factor PrfB, which is required for the proper translation and stability of UGA-containing transcripts in chloroplasts [ ].
Short Name  PrfB

0 Child Features

2 Gene Families

163 Genes

3 Ontology Annotations

0 Parent Features

14 Publications

USDA
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