v5.1.0.3
Glycine data from LIS
Type | Domain |
Description | Peptide chain release factors (RFs) are required for the termination of protein biosynthesis [ ]. At present two classes of RFs can be distinguished. Class I RFs bind to ribosomes that have encountered a stop codon at their decoding site and induce release of the nascent polypeptide. Class II RFs are GTP-binding proteins that interact with class I RFs and enhance class I RFactivity. In prokaryotes there are two class I RFs that act in a codon specific manner [ ]: RF-1(gene prfA) mediates UAA and UAG-dependent termination while RF-2 (gene prfB) mediates UAA and UGA-dependent termination. RF-1 and RF-2 are structurally and evolutionary related proteins which have been shown to be part of a larger family []. |
Short Name | Pep_chain_release_fac_I |