Protein Domain : Nuclear transport factor 2 domain IPR002075

Type  Domain
Description  This entry represent the main structural domain of NTF2 and related domains.Nuclear transport factor 2 (NTF2) is a homodimer which stimulates efficient nuclear import of a cargo protein. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins. NTF2 folds into a cone with a deep hydrophobic cavity, the opening of which is surrounded by several negatively charged residues. RanGDP binds to NTF2 by inserting a conserved phenylalanine residue into the hydrophobic pocket of NTF2 and making electrostatic interactions with the conserved negatively charged residues that surround the cavity [ ].
Short Name  NTF2_dom
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1 Child Features

Trail: ProteinDomain

7 Gene Families

Trail: ProteinDomain

1000 Genes

Trail: ProteinDomain

0 Ontology Annotations

0 Parent Features

14 Publications

Trail: ProteinDomain
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