Ontology Term : Pfam:PF03661 Transmembrane protein 33/Nucleoporin POM33 EMBL-EBI

Description  This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores [1]. Proteins in this entry also include Tts1 from fission yeasts [2], Kr-h2 (krueppel homologue 2) from flies [3] and TMEM33 from vertebrates [4]. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator [2]. Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression [3]. TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons [4].
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