v5.1.0.3
Glycine data from LIS
Type | Domain |
Description | The Ccr4-Not complex controls mRNA metabolism at multiple levels in eukaryotic cells [ , , ]. This complex is a major cytoplasmic deadenylase consisting of a combination of at least nine subunits, four of which have deadenylase activity []. The conserved core of the CCR4-NOT complex consists of two major modules: a catalytic module comprising two deadenylases (CAF1 or its paralogue POP2, and CCR4a or its paralogue CCR4b) and the NOT module, which minimally consists of NOT1, NOT2 and NOT3 [].This entry represents the C-terminal domain of NOT2, NOT3 and NOT5 (subunits 2, 3 and 5 of the complex). The C-terminal regions of NOT2 and NOT3 contain a conserved SH3-like NOT-box domain which mediates NOT-module assembly [ ]. |
Short Name | NOT2/3/5_C |