Protein Domain : NOT2/NOT3/NOT5, C-terminal IPR007282

Type  Domain
Description  The Ccr4-Not complex controls mRNA metabolism at multiple levels in eukaryotic cells [ , , ]. This complex is a major cytoplasmic deadenylase consisting of a combination of at least nine subunits, four of which have deadenylase activity []. The conserved core of the CCR4-NOT complex consists of two major modules: a catalytic module comprising two deadenylases (CAF1 or its paralogue POP2, and CCR4a or its paralogue CCR4b) and the NOT module, which minimally consists of NOT1, NOT2 and NOT3 [].This entry represents the C-terminal domain of NOT2, NOT3 and NOT5 (subunits 2, 3 and 5 of the complex). The C-terminal regions of NOT2 and NOT3 contain a conserved SH3-like NOT-box domain which mediates NOT-module assembly [ ].
Short Name  NOT2/3/5_C

0 Child Features

1 Gene Families

414 Genes

1 Ontology Annotations

0 Parent Features

14 Publications

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