Protein Domain : Mediator of RNA polymerase II transcription subunit 25, von Willebrand factor type A domain IPR021419

Type  Domain
Description  The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain which is this one, an SD2 domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This VWA or von Willebrand factor type A domain when bound to RAR and the histone acetyltransferase CBP is responsible for recruiting Med1 to the rest of the Mediator complex [].
Short Name  Mediator_Med25_VWA
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0 Child Features

3 Gene Families

Trail: ProteinDomain

296 Genes

Trail: ProteinDomain

0 Ontology Annotations

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14 Publications

Trail: ProteinDomain
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