Ontology Term : Pfam:PF01699 Sodium/calcium exchanger protein EMBL-EBI
Description  This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells [2]. Ca2+ is moved into or out of the cytosol depending on Na+ concentration [2]. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3 [1] see Swiss:Q01728, Swiss:P48768 and Swiss:P70549 respectively.
Namespace  Family
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