Ontology Term : Pfam:PF04061 ORMDL family EMBL-EBI

Description  Evidence form [1] suggests that ORMDLs are involved in protein folding in the ER. Orm proteins have been identified as negative regulators of sphingolipid synthesis that form a conserved complex with serine palmitoyltransferase, the first and rate-limiting enzyme in sphingolipid production. This novel and conserved protein complex, has been termed the SPOTS complex (serine palmitoyltransferase, Orm1/2, Tsc3, and Sac1).
Namespace  Family

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55 Data Sets

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1 Ontology

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325 Ontology Annotations

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