Ontology Term : Pfam:PF12530 Focadhesin/RST1, DUF3730 EMBL-EBI

Description  This domain of unknown function is found in Focadhesin from animals and RST1 (RESURRECTION 1) from plants. Focadhesin (FOCAD) is a focal adhesion protein with potential tumour suppressor function in gliomas [1]. RST1 was originally identified in a genetic screen for factors involved in the biosynthesis of epicuticular waxes [2]. Later, RST1 and RST1 INTERACTING PROTEIN (RIPR) have been shown to act as cofactors of the cytoplasmic exosome and the Ski complex in plants [3]. It is involved in the suppression of siRNA-mediated silencing of transgenes and certain endogenous transcripts [4]. Structure predictions suggest that this is an alpha-helical domain with and armadillo-like fold.
Namespace  Domain

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56 Data Sets

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