Protein Domain : Solute-binding protein family 3/N-terminal domain of MltF IPR001638

Type  Domain
Description  Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [ , ]. On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped [ ] into eight families or clusters, which generally correlate with the nature of the solute bound.This entry represents a domain found in the solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. This domain can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. MltF is a murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product [ ].Familiy 3 members include:Histidine-binding protein (gene hisJ) of Escherichia coli and related bacteria. An homologous lipoprotein exists in Neisseria gonorrhoeae. Lysine/arginine/ornithine-binding proteins (LAO) (gene argT) of Escherichia coli and related bacteria are involved in the same transport system than hisJ. Both solute-binding proteins interact with a common membrane-bound receptor hisP of the binding protein dependent transport system HisQMP. Glutamine-binding proteins (gene glnH) of Escherichia coli and Bacillus stearothermophilus.Glutamate-binding protein (gene gluB) of Corynebacterium glutamicum. Arginine-binding proteins artI and artJ of Escherichia coli. Nopaline-binding protein (gene nocT) from Agrobacterium tumefaciens. Octopine-binding protein (gene occT) from Agrobacterium tumefaciens. Major cell-binding factor (CBF1) (gene: peb1A) from Campylobacter jejuni. Bacteroides nodosus protein aabA. Cyclohexadienyl/arogenate dehydratase of Pseudomonas aeruginosa, a periplasmic enzyme which forms an alternative pathway for phenylalanine biosynthesis. Escherichia coli L-cystine-binding protein TcyJ, previously known as protein fliY.Vibrio harveyi protein patH. Bacillus subtilis Probable ABC transporter extracellular-binding protein yckB. Bacillus subtilis L-cystine-binding protein TcyA, also known as yckK.
Short Name  Solute-binding_3/MltF_N

2 Child Features

12 Gene Families

1000 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

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