Protein Domain : Transcription factor DP, C-terminal IPR014889

Type  Domain
Description  The transcription factor DP (dimerization partner) forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer [ ] and negatively regulates the G1-S transition. Though originally the role of DP in transcriptional activation was thought to be facilitating the binding of E2F to target DNA, it was latter shown that the C-terminal acidic region of DP1 binds strongly to the PH domain of p62 of TFIIH and acts as a transactivation domain [ ].
Short Name  Transc_factor_DP_C
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235 Genes

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13 Publications

Trail: ProteinDomain
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