Protein Domain : Transthyretin, conserved site IPR023419

Type  Conserved_site
Description  Transthyretin (prealbumin) is a thyroid hormone-binding protein that seems to transport thyroxine (T4) from the bloodstream to the brain. It is a protein of about 130 amino acids that assembles as a homotetramer and forms an internal channel that binds thyroxine. In humans, transthyretin is mainly synthesized in the brain choroid plexus; variants of the protein are associated with distinct forms of amyloidosis. The sequence of transthyretin is highly conserved in vertebrates. A number of uncharacterised proteins also belong to this family: Escherichia coli hypothetical protein YedX. Bacillus subtilis hypothetical protein YunM. Caenorhabditis elegans hypothetical protein R09H10.3. Caenorhabditis elegans hypothetical protein ZK697.8. The signature pattern in this entry is located at the C terminus.
Short Name  Transthyretin_CS

0 Child Features

0 Gene Families

102 Genes

0 Ontology Annotations

0 Parent Features

12 Publications

USDA
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