Protein Domain : Heat shock transcription factor family IPR027725

Type  Family
Description  In eukaryotes heat shock factors (HSFs) induce transcription of heat shock genes following stress and in response to developmental signals [ ]. HSFs recognise cis-acting promoter elements composed of variations of an inverted repeat called heat shock elements (HSE) []. Both HSF and HSEs are conserved in their fundamental structures from yeast to humans.In general, HSFs contain an N-terminal DNA-binding domain of the helix-turn-winged helix type, one or more coiled-coil trimerisation domains, nuclear localisation domains, and a C-terminal trans-activation domain [ ]. HSF is present in a latent state under normal conditions; it is activated upon heat stress by induction of trimerisation and high-affinity binding to DNA and by exposure of domains for transcriptional activity [].
Short Name  HSF_fam

1 Child Features

18 Gene Families

1000 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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