v5.1.0.3
Glycine data from LIS
Type | Family |
Description | In eukaryotes heat shock factors (HSFs) induce transcription of heat shock genes following stress and in response to developmental signals [ ]. HSFs recognise cis-acting promoter elements composed of variations of an inverted repeat called heat shock elements (HSE) []. Both HSF and HSEs are conserved in their fundamental structures from yeast to humans.In general, HSFs contain an N-terminal DNA-binding domain of the helix-turn-winged helix type, one or more coiled-coil trimerisation domains, nuclear localisation domains, and a C-terminal trans-activation domain [ ]. HSF is present in a latent state under normal conditions; it is activated upon heat stress by induction of trimerisation and high-affinity binding to DNA and by exposure of domains for transcriptional activity []. |
Short Name | HSF_fam |