Protein Domain : Exportin-2, C-terminal IPR005043

Type  Domain
Description  Exportin-2, also known as CAS, is an export receptor for importin-alpha [ ]. It binds strongly to importin alpha only in the presence of RanGTP, forming an importin alpha/CAS/RanGTP complex. Exportin-2 mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm [].This entry represents the C-terminal domain of XPO2. Structural studies of its yeast homologue, Cse1, indicate that this domain binds to both the transport-orchestrating protein RanGTP and the cargo molecule that is being exported [ ].
Short Name  XPO2_C

0 Child Features

0 Gene Families

115 Genes

2 Ontology Annotations

0 Parent Features

13 Publications

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