v5.1.0.3
Glycine data from LIS
Type | Family |
Description | The eukaryotic defective in cullin neddylation (DCN) protein family, contributes to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. These multi-protein complexes are required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome [ , , ]. Proteins in the DCN family include:Yeast DCN1.Vertebrate DCN1-like protein 1-5.Plant Defective in cullin neddylation protein AAR3 [ ].DCN family proteins all contain a Potentiating neddylation (PONY) domain ( ), contains a cullin-binding surface within its C-terminal region and is sufficient to promote neddylation [ , ]. The N-terminal region of the protein often contains a UBA-like domain. |
Short Name | DCN-prot |