Protein Domain : Defective-in-cullin neddylation protein IPR014764

Type  Family
Description  The eukaryotic defective in cullin neddylation (DCN) protein family, contributes to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. These multi-protein complexes are required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome [ , , ]. Proteins in the DCN family include:Yeast DCN1.Vertebrate DCN1-like protein 1-5.Plant Defective in cullin neddylation protein AAR3 [ ].DCN family proteins all contain a Potentiating neddylation (PONY) domain ( ), contains a cullin-binding surface within its C-terminal region and is sufficient to promote neddylation [ , ]. The N-terminal region of the protein often contains a UBA-like domain.
Short Name  DCN-prot

0 Child Features

4 Gene Families

418 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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