LIS - Legume Information System
Information about legume traits for crop improvement
GlycineMine
v5.1.0.3
Glycine data from LIS
v5.1.0.3
Glycine data from LIS
| Type | Family |
| Description | The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylatedduring the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substratebefore, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute differentadditional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of acatalytically essential acidic residue. The superfamily may be divided into two main branches. The relationship between the two branches isnot evident by (PSI-)BLAST but is clear from more sensitive sequence searches and structural comparisons [].The smaller clade-2 is composed mainly of acid phosphatases and phytases. Acid phosphatases are a heterogeneous group of proteins that hydrolyse phosphate esters, optimally at low pH. The catalytic functions of these proteins include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatase. Fungal phytases are histidine acid phosphatases that catalyse the hydrolysis of phytate (myo-inositol hexakisphosphate) to myo-inositol and inorganic phosphate [ , ].Included in this group are:Escherichia coli pH 2.5 acid phosphatase (gene appA).E. coli glucose-1-phosphatase ( ) (gene agp). Yeast constitutive and repressible acid phosphatases (genes PHO3 and PHO5).Schizosaccharomyces pombe acid phosphatase (gene pho1).Aspergillus awamori phytases A and B ( ) (gene phyA and phyB). Mammalian lysosomal and prostatic acid phosphatase.Several Caenorhabditis elegans hypothetical proteins. |
| Short Name | His_Pase_clade-2 |
