v5.1.0.3
Glycine data from LIS
Type | Domain |
Description | The PHP (Polymerase and Histidinol Phosphatase) domain has four conserved sequence motifs that contain invariant histidine and aspartate residues implicated in metal ion coordination. It is found in alpha-subunit of bacterial DNA polymerase III () and family X DNA polymerases in addition to histidinol phosphatase ( ) [ , ]. As part of DNA polymerases, the PHP domain was suggested to hydrolyse pyrophosphate []. This family is often associated with an N-terminal region . This domain has a distorted (α/β)7 barrel fold [ ]. |
Short Name | PHP_dom |