Protein Domain : PHP domain IPR004013

Type  Domain
Description  The PHP (Polymerase and Histidinol Phosphatase) domain has four conserved sequence motifs that contain invariant histidine and aspartate residues implicated in metal ion coordination. It is found in alpha-subunit of bacterial DNA polymerase III () and family X DNA polymerases in addition to histidinol phosphatase ( ) [ , ]. As part of DNA polymerases, the PHP domain was suggested to hydrolyse pyrophosphate []. This family is often associated with an N-terminal region . This domain has a distorted (α/β)7 barrel fold [ ].
Short Name  PHP_dom

1 Child Features

0 Gene Families

147 Genes

1 Ontology Annotations

0 Parent Features

13 Publications

USDA
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