Protein Domain : TraB/PrgY/GumN family IPR002816

Type  Family
Description  This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora Enterococcus faecalis and gumN from the plant pathogen Xanthomonas. Tiki1 is homologous to TraB/PrgY. They have a pair of widely spaced GX2H motifs and a conserved glutamate. From the structural study, this group of proteins have been identified as an ancient metalloprotease clan with a common protein architecture -cobbled from the folds of the EreA/ChaN/PMT group- that mediates proteolytic activities [ ]. Tiki1 is a membrane-associated protease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors [ ].TraB/PrgY is an inhibitor peptide that may act as a protease to inactivate the mating pheromone [ ].
Short Name  TraB/PrgY/GumN_fam

3 Child Features

3 Gene Families

174 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
InterMine logo
The Legume Information System (LIS) is a research project of the USDA-ARS:Corn Insects and Crop Genetics Research in Ames, IA.
LegumeMine || ArachisMine | CicerMine | GlycineMine | LensMine | LupinusMine | PhaseolusMine | VignaMine | MedicagoMine
InterMine © 2002 - 2022 Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom