Protein Domain : Protein KTI12/L-seryl-tRNA(Sec) kinase IPR013641

Type  Family
Description  Kti12 associates with Elongator complex, a six-subunit histone acetytransferase complex that functions with the elongating form of RNA polymerase II during transcription [ ]. It is not a structural subunit but may play a regulatory role in Elongator function []. It has been shown that Kti12 is associated with chromatin throughout the genome, even in non-transcribed regions and in the absence of Elongator []. It is required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA [].L-seryl-tRNA(Sec) kinase (PSTK) specifically phosphorylates seryl-tRNA(Sec) to O-phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis [ ].
Short Name  KTI12/PSTK

2 Child Features

1 Gene Families

68 Genes

0 Ontology Annotations

0 Parent Features

13 Publications

USDA
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