v5.1.0.3
Glycine data from LIS
Type | Family |
Description | Sulfiredoxins belong to the oxidoreductase family, which are involved in cellular responses to oxidative stress [ ]. They catalyse the reaction peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-RIt is a member of a conserved family of eukaryotic antioxidants and contains a conserved C-terminal cysteine which is essential for its antioxidant function.Sulfiredoxin (Srx) plays a role in signalling through the catalytic reduction of oxidative modifications. It is responsible for the regulation of peroxiredoxin (Prx) by catalysing reduction of the conserved cysteine from sulfinic to sulfenic acid. This reduction prevents further reduction to sulfonic acid, which ultimately results in degradation.Srx also has a role in glutathionylation. |
Short Name | Sulfiredoxin |