v5.1.0.3
Glycine data from LIS
Type | Family |
Description | Diphthine synthase ( ), also known as diphthamide biosynthesis S-adenosylmethionine-dependent methyltransferase, participates in the modification of a specific histidine residue in elongation factor 2 (EF-2) of eukaryotes and archaea to diphthamide. It is required for the methylation step in dipthamide biosynthesis. This entry also includes diphthine methyl ester synthase ( ) from Saccharomyces cerevisiae (a product of the DPH5 gene), which is an S-adenosyl-L-methionine-dependent methyltransferase that catalyzes methylations of a modified histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester: the second step of diphthamide biosynthesis [ ]. |
Short Name | Dphthn_synthase |