v5.1.0.3
Glycine data from LIS
Type | Family |
Description | Sec15 is a component of the exocyst complex involved in the the tethering of post-Golgi Golgi secretory vesicles to the plasma membrane during exocytosis and plays a role in several cellular functions such as cell polarisation, cytokinesis, ciliogenesis and tumour invasion. The exocyst is one of the members of the complexes associated with tethering containing helical rods (CATCHR), together with COG, GARP, and Dsl1 complexes, which share a fold consisting of α-helical bundles forming a rod structure [ , ]. Its C-terminal domain mediates Rab GTPases binding which occurs in a GTP-dependent manner []. |
Short Name | EXOC6/Sec15 |