v5.1.0.3
Glycine data from LIS
Type | Domain |
Description | The VHS domain is an about 150 residues long domain, whose name is derived from its occurrence in VPS-27, Hrs and STAM. The VHS domain is found at the N-termini of proteins associated with endocytocis and/or vesicular trafficking, often in association with other domains like FYVE, SH3 or TAM [, ]. The VHS domain of Hrs makes both intra- andintermolecular interactions with FYVE domains and it has been proposed that it might as well interact with other domains. The VHS domain might function as amultipurpose docking adapter that localizes proteins to the membrane through interactions with the membrane and/or the endocytic machinery [, ].Resolution of the crystal structure of the VHS domain of Drosophila Hrs and human Tom1 revealed that it consists of eight helices arranged in a superhelix[ , ]. |
Short Name | VHS_dom |