Ontology Term : Pfam:PF14724 Mitochondrial-associated sphingomyelin phosphodiesterase EMBL-EBI

Description  The GO annotation for this family indicates that it is a single-pass membrane protein, and it appears to be found in mitochondrial membranes. Sphingolipids play important roles in regulating cellular responses, and although mitochondria contain sphingolipids, direct regulation of their levels in mitochondria or mitochondria-associated membranes is mostly unclear. Sphingomyelin phosphodiesterases catalyse the hydrolysis of sphingomyelin to ceramide and phosphocholine, and these metabolites are involved in signalling pathways.
Namespace  Family

0 Cross References

21 Data Sets

Trail: OntologyTerm

1 Ontology

Trail: OntologyTerm

42 Ontology Annotations

Trail: OntologyTerm

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0 Synonyms

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