v5.1.0.3
Glycine data from LIS
Type | Family |
Description | This entry represents mycolic acid cyclopropane synthases and related enzymes, including CmaA1, CmaA2 (cyclopropane mycolic acid synthase A1 and A2), MmaA1-4 (methoxymycolic acid synthase A1-4) and tuberculostearic acid methyltransferase UfaA1. All are thought to be S-adenosyl-L-methionine (SAM) utilising methyltransferases [ ]. This entry also includes S-adenosylmethionine-dependent methyltransferase UmaA from Mycobacterium tuberculosis, which is a methyltransferase that modifies short-chain fatty acids [].Mycolic acid cyclopropane synthase or cyclopropane-fatty-acyl-phospholipid synthase (CFA synthase) catalyses the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid ->S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. The major mycolic acid produced by Mycobacterium tuberculosis contains two cis-cyclopropanes in the meromycolate chain. Cyclopropanation may contribute to the structural integrity of the cell wall complex [ ]. |
Short Name | Mycolic_cyclopropane_synthase |