Protein Domain : Mycolic acid cyclopropane synthase IPR003333

Type  Family
Description  This entry represents mycolic acid cyclopropane synthases and related enzymes, including CmaA1, CmaA2 (cyclopropane mycolic acid synthase A1 and A2), MmaA1-4 (methoxymycolic acid synthase A1-4) and tuberculostearic acid methyltransferase UfaA1. All are thought to be S-adenosyl-L-methionine (SAM) utilising methyltransferases [ ]. This entry also includes S-adenosylmethionine-dependent methyltransferase UmaA from Mycobacterium tuberculosis, which is a methyltransferase that modifies short-chain fatty acids [].Mycolic acid cyclopropane synthase or cyclopropane-fatty-acyl-phospholipid synthase (CFA synthase) catalyses the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid ->S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. The major mycolic acid produced by Mycobacterium tuberculosis contains two cis-cyclopropanes in the meromycolate chain. Cyclopropanation may contribute to the structural integrity of the cell wall complex [ ].
Short Name  Mycolic_cyclopropane_synthase

0 Child Features

3 Gene Families

302 Genes

1 Ontology Annotations

0 Parent Features

14 Publications

USDA
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