Protein Domain : YTH domain IPR007275

Type  Domain
Description  The YTH (YT521-B homology) domain has been suggested to be an evolutionarily conserved m6A-dependent RNA binding domain [ ]. Proteins containing this domain includes mammalian YTHD and YTDC proteins, Arabidopsis CPSF30 (At1g30460), budding yeast Pho92 and fission yeast Mmi1. In Saccharomyces cerevisiae, Pho92 is a post-transcriptional regulator that regulates Pho4 mRNA stability by binding to the 3'-UTR in a phosphate-dependent manner. Its YTH domain exhibits RNA-binding activity [ ]. In Schizosaccharomyces pombe, Mmi1 has been identified as eliminating meiosis-specific mRNAs []. Rat YTHDC1 (also known as YT521-B) is an alternative splicing regulator that recognises and binds N6-methyladenosine (m6A)-containing RNAs. The YTH domain of YT521-B is a RNA-binding domain with a very degenerate sequence-specificity [ ].
Short Name  YTH_domain
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0 Child Features

8 Gene Families

Trail: ProteinDomain

1000 Genes

Trail: ProteinDomain

1 Ontology Annotations

Trail: ProteinDomain

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14 Publications

Trail: ProteinDomain
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